Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
Pope Francis, remains in critical condition battling double pneumonia, but had a "good" night in hospital, slept and is resting, the Vatican said on Monday.
Ukraine President Volodymyr Zelenskyy says he is willing to give up his position if it means peace in Ukraine, adding that he could exchange his departure for his country's entry into the NATO military alliance.
Israel on Sunday said it will not tolerate presence of Hayat Tahrir al-Sham (HTS) in southern Syria, nor any other forces affiliated with the country's new rulers, and demanded the territory be demilitarised.
Talks with Israel through mediators on further steps in a ceasefire agreement are conditional on Palestinian prisoners being released as agreed, Hamas official Basem Naim said on Sunday.
Friedrich Merz, who set to become Germany's next chancellor after his opposition conservatives won the national election on Sunday, vowed to help give Europe "real independence" from the US as he prepared to cobble together a government.